William Edward Woodruff (24 December 1795–19 June 1885) was an early American politician and a pioneer journalist of Arkansas.
Born on a Long Island, New York farm, Woodruff was apprenticed to a Sag Harbor printer at the age of 14, and in 1818 headed west to work in Kentucky, Tennessee, and finally the newly created state of Arkansas, printing the first edition of the Arkansas Gazette in 1819.
Woodruff County, Arkansas is named after him.